An Efficient Chemoenzymatic Approach towards the Synthesis of Rugulactone.
نویسندگان
چکیده
Rugulactone is a natural product isolated from the plant Cryptocarya rugulosa. It has shown very important biological activity as an inhibitor of the nuclear factor κB (NF-κB) activation pathway. A new chemoenzymatic approach towards the synthesis of rugulactone is presented here. The chirality, induced to the key intermediate by a stereoselective enzymatic reduction utilizing NADPH-dependent ketoreductase, is described in detail.
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عنوان ژورنال:
- Molecules
دوره 23 3 شماره
صفحات -
تاریخ انتشار 2018